Contact
Grousbeck Gene Therapy Center
MEE/SERI – 2W
20 Staniford Street
Boston, MA 02114
617-573-6307
Directions & Parking
Directions
If entering from SERI main entrance (20 Staniford Street, Boston, MA 02114):
- Please check in at the front desk upon arrival who will give the admin a call (617-573-6307) to escort you through the building
- Directions to follow blue arrows to Grousbeck Center:
- Walk upstairs to second floor, down hallway passed SERI cafeteria and take left at 2nd floor conference room
- Take next quick right after 2nd floor conference room
- Walk down long hallway over SERI/ Simches bridge & down ramp to SERI 2-west
- Take second right (following blue arrows directing to Starr Center)
- Walk straight towards Grousbeck Center for Gene Therapy sign at end of the hallway
If entering from Simches Center (185 Cambridge Street, Boston, MA 02114):
- Enter in lobby to the right (without security desk)
- Take elevator to the 2nd floor
- Take a right to approach SERI entrance
- The door will be locked. Please call the admin at 617-573-6307 upon arrival
Parking Options
50 Staniford Street garage
- The garage is located under the building and the entrance is on Staniford Street. Before returning to your vehicle, pay for parking at the pay station in the garage. They accept most major credit cards. Cash is not accepted. Parking rates are subject to change.
- Rates:
Up to 1 hour ……………….$12.00
1 to 2.5 hours………………$24.00
2.5 to 12 hours…………….$36.00
12 to 24 hours……………..$48.00
Cambridge River Plaza (209 Cambridge Street)
- Amex, Bills, Coins, Debit card, Discover, MC/Visa all accepted
- Rates:
1 hour ……………….$12.00
2 hours ………………$24.00
3 hours …………….$36.00
4 hours ……………..$48.00
Request Vectors
To apply for a quote, please complete this GTVC Request Form and submit by emailing (gtvc@meei.harvard.edu) or faxing (617-912-0114) to the GTVC core.
- With quote, apply for PO # from your Institute (internal MEEI/SERI users can provide a grant/fund number to charge for the service)
- For the customized vectors, submit plasmid DNA
Plasmid:
- The user is required to provide the GTVC core with DNA prepared with an Endotoxin-free purification kit (Qiagen preferred).
- For MIDI prep werequire 500ug, for MINI prep13ug DNA. While these kits are commercially available, we offer a DNA purification service. Keep in mind that the quality of your DNA significantly affects quite the final titer of your virus.
The GTVC core will also request the following information:
- A clear map of the plasmid and a picture of restriction digests confirming the integrity of the plasmid and the ITR region.
- Fullsequence from ITR – ITR (Vector nti prefered) service. Keep in mind that the quality of your DNA significantly affects quite the final titer of your virus.
Submission is not complete without sequence and digest information. Incomplete information will delay production.
Request Reagents
Interested to obtain one of the Vandenberghe lab reagents? We aim at depositing all plasmid material on Addgene.org available under UBMTA for academic researchers and non-human research. Others please contact luk_vandenberghe at meei.harvard.edu. AAV vector preparations can be obtained through the Gene Transfer Vector Core and can be reached on gtvc@meei.harvard.edu.
Note: Regarding Anc AAV vector requests, we are trying to respond as quickly as possible to all requests, please bear with us.
Positions
We are always interested in talented and passionate researchers who work well in a team and compelled by gene therapy and virology. Prospective applicants can send an email to luk_vandenberghe at meei.harvard.edu with a CV, cover letter, and list of 3 references. Please provide your materials in one document and filename as YYMMDD_LASTNAME_FIRSTNAME.
Graduate Student Positions
- HMS Ph.D. Program in Virology
- HMS Ph.D. Program in Biological and Biomedical Sciences (BBS)
- Leder Human Biology and Translational Medicine
- Therapeutics Graduate Program
- Students in other programs are invited to apply including Systems Biology and Immunology.
Postdoctoral Positions
- Protein Engineering, Molecular Viral Library Development and Evaluation: development of adeno-associated viral vector design and evaluation thereof using NGS and high-throughput technologies
- Viral Immunology and Host-Vector Interactions: Study of the host response of novel molecular viral vectors in animal models and humans
- Bio-informatics and Systems Biology: Study of large datasets on vector-host interactions relevant to gene therapy in order to obtain systems understanding of the interplay between host genomics and viral vector structure.
- In vivo gene transfer and Translational Gene Therapy: evaluation of the safety and targeting potential of novel viral vectors for therapeutic gene transfer in animal models and disease models, with a focus on retina, cochlea, liver, muscle, heart and/or liver.
Scientific Staff Positions
- Protein Engineering, Molecular Viral Library Development and Evaluation: development of adeno-associated viral vector design and evaluation thereof using NGS and high-throughput technologies
- Viral Immunology and Host-Vector Interactions: Study of the host response of novel molecular viral vectors in animal models and humans
- In vivo gene transfer and Translational Gene Therapy: evaluation of the safety and targeting potential of novel viral vectors for therapeutic gene transfer in animal models and disease models, with a focus on retina, cochlea, liver, muscle, heart and/or liver.
Graduate Student Positions
Students of all Harvard programs are welcome. Dr. Vandenberghe is faculty in the following Graduate Programs:
Competitive prospective applicants can send an email to vandenberghe.lab@gmail.com with a CV, cover letter, and list of 3 references. Please provide your materials in one document and filename as YYMMDD_LASTNAME_FIRSTNAME.
Postdoctoral Positions
Several postdoctoral fellowship positions are available within a range of expertises and interest.
Competitive prospective applicants can send an email to vandenberghe.lab@gmail.com with a CV, cover letter, and list of 3 references. Please provide your materials in one document and filename as YYMMDD_LASTNAME_FIRSTNAME.
Scientific Staff Positions
A few senior scientific staff positions are available within the Vandenberghe laboratory.
Prospective applicants can send an email to vandenberghe.lab@gmail.com with a CV, cover letter, and list of 3 references. Please provide your materials in one document and filename as YYMMDD_LASTNAME_FIRSTNAME.