Contact
Grousbeck Gene Therapy Center
MEE/SERI – 2W
20 Staniford Street
Boston, MA 02114
617-573-6307
Directions & Parking
Directions
If entering from SERI main entrance (20 Staniford Street, Boston, MA 02114):
- Please check in at the front desk upon arrival who will give the admin a call (617-573-6307) to escort you through the building
- Directions to follow blue arrows to Grousbeck Center:
- Walk upstairs to second floor, down hallway passed SERI cafeteria and take left at 2nd floor conference room
- Take next quick right after 2nd floor conference room
- Walk down long hallway over SERI/ Simches bridge & down ramp to SERI 2-west
- Take second right (following blue arrows directing to Starr Center)
- Walk straight towards Grousbeck Center for Gene Therapy sign at end of the hallway
If entering from Simches Center (185 Cambridge Street, Boston, MA 02114):
- Enter in lobby to the right (without security desk)
- Take elevator to the 2nd floor
- Take a right to approach SERI entrance
- The door will be locked. Please call the admin at 617-573-6307 upon arrival
Parking Options
50 Staniford Street garage
- The garage is located under the building and the entrance is on Staniford Street. Before returning to your vehicle, pay for parking at the pay station in the garage. They accept most major credit cards. Cash is not accepted. Parking rates are subject to change.
- Rates:
Up to 1 hour ……………….$12.00
1 to 2.5 hours………………$24.00
2.5 to 12 hours…………….$36.00
12 to 24 hours……………..$48.00
Cambridge River Plaza (209 Cambridge Street)
- Amex, Bills, Coins, Debit card, Discover, MC/Visa all accepted
- Rates:
1 hour ……………….$12.00
2 hours ………………$24.00
3 hours …………….$36.00
4 hours ……………..$48.00
Request Vectors
To apply for a quote, please complete this GTVC Request Form and submit by emailing (gtvc@meei.harvard.edu) or faxing (617-912-0114) to the GTVC core.
- With quote, apply for PO # from your Institute (internal MEEI/SERI users can provide a grant/fund number to charge for the service)
- For the customized vectors, submit plasmid DNA
Plasmid:
- The user is required to provide the GTVC core with DNA prepared with an Endotoxin-free purification kit (Qiagen preferred).
- For MIDI prep werequire 500ug, for MINI prep13ug DNA. While these kits are commercially available, we offer a DNA purification service. Keep in mind that the quality of your DNA significantly affects quite the final titer of your virus.
The GTVC core will also request the following information:
- A clear map of the plasmid and a picture of restriction digests confirming the integrity of the plasmid and the ITR region.
- Fullsequence from ITR – ITR (Vector nti prefered) service. Keep in mind that the quality of your DNA significantly affects quite the final titer of your virus.
Submission is not complete without sequence and digest information. Incomplete information will delay production.
Request Reagents
Interested to obtain one of the Vandenberghe lab reagents? We aim at depositing all plasmid material on Addgene.org available under UBMTA for academic researchers and non-human research. Others please contact luk_vandenberghe at meei.harvard.edu. AAV vector preparations can be obtained through the Gene Transfer Vector Core and can be reached on gtvc@meei.harvard.edu.
Note: Regarding Anc AAV vector requests, we are trying to respond as quickly as possible to all requests, please bear with us.
Positions
We are always interested in talented and passionate researchers who work well in a team and compelled by gene therapy and virology. Prospective applicants can send an email to luk_vandenberghe at meei.harvard.edu with a CV, cover letter, and list of 3 references. Please provide your materials in one document and filename as YYMMDD_LASTNAME_FIRSTNAME.
Graduate Student Positions
- HMS Ph.D. Program in Virology
- HMS Ph.D. Program in Biological and Biomedical Sciences (BBS)
- Leder Human Biology and Translational Medicine
- Therapeutics Graduate Program
- Students in other programs are invited to apply including Systems Biology and Immunology.
Postdoctoral Positions
- Protein Engineering, Molecular Viral Library Development and Evaluation: development of adeno-associated viral vector design and evaluation thereof using NGS and high-throughput technologies
- Viral Immunology and Host-Vector Interactions: Study of the host response of novel molecular viral vectors in animal models and humans
- Bio-informatics and Systems Biology: Study of large datasets on vector-host interactions relevant to gene therapy in order to obtain systems understanding of the interplay between host genomics and viral vector structure.
- In vivo gene transfer and Translational Gene Therapy: evaluation of the safety and targeting potential of novel viral vectors for therapeutic gene transfer in animal models and disease models, with a focus on retina, cochlea, liver, muscle, heart and/or liver.
Scientific Staff Positions
- Protein Engineering, Molecular Viral Library Development and Evaluation: development of adeno-associated viral vector design and evaluation thereof using NGS and high-throughput technologies
- Viral Immunology and Host-Vector Interactions: Study of the host response of novel molecular viral vectors in animal models and humans
- In vivo gene transfer and Translational Gene Therapy: evaluation of the safety and targeting potential of novel viral vectors for therapeutic gene transfer in animal models and disease models, with a focus on retina, cochlea, liver, muscle, heart and/or liver.
Program Coordinator
- Facilitate various projects in coordination with internal team members and colleagues in departments within MEEI and Mass General Brigham (MGB) to further support initiatives within the faculty’s research programs at the Grousbeck Gene Therapy Center. Knowledge of development/donor proposals, grant administration, clinical research projects, and personnel management preferred.
- Conducts routine data entry of weekly and monthly time reporting.
- Assists the Department and Research Faculty with event and travel planning including hosted dinners or seminars.
- Following established event planning methods, is responsible for events hosted by the Grousbeck Gene Therapy Center and other events as requested.
- Makes travel arrangements, hotel accommodations, and other necessary arrangements for conferences and meeting attendance. Monitors and resolves all financial arrangements.
- Assist Department and Research Faculty with travel to meetings and events.
- Provides as necessary administrative support for travel arrangements.
- Prepares travel reimbursement requests ensuring compliance with MEEI/MGB travel reimbursement policies. Reviews travel reimbursement requests of research staff assisting staff in their completion of travel reimbursements that meet MEEI/MGB requirements.
- Processes travel reimbursement and check requests.
- Reconciles MGB corporate credit card charges and expense reports per MEEI/MGB policy, as needed.
- Assist faculty with maintenance of curriculum vitae, biosketches, calendar, including scheduling meetings, appointments, and conference rooms.
- Assist with updating lab website content.
- Assist with recruiting and onboarding new employee, researchers, or sponsored staff with HR.
- Liaison functions with facilities, HR, payroll and finance departments.
- Improve workplace organization and communication.
- Letter drafting
- Responds to incoming telephone calls following department protocol, responds to questions that are appropriate and refers and/or takes complete messages.
- Creates and maintains special project work files; keeps file documentation current, correct, and complete to facilitate workflow.
- Additional duties as assigned.
- Bachelor’s Degree required.
- Strong demonstrated organizational skills, with proven experience prioritizing work and coordinating multiple projects simultaneously.
- Meticulous, precise, efficient, and organized.
- Excellent oral, written and interpersonal skills.
- Experienced user of MS Office (Word, Excel, PowerPoint). Preferred: Adobe Photoshop and/or Illustrator, nimble in learning additional software packages (e.g. Endnote, Scientific graphing)
- Proven ability to work closely with faculty and laboratory staff.
- Ability to work in a fast-paced environment with highly varied parallel tasks
- Exceptional problem solving, critical thinking and customer service skills.
- Ability to take on new tasks and adapt to different work assignments and personalities.
- Ability to take initiative and work with minimal direction.
Graduate Student Positions
Students of all Harvard programs are welcome. Dr. Vandenberghe is faculty in the following Graduate Programs:
Competitive prospective applicants can send an email to vandenberghe.lab@gmail.com with a CV, cover letter, and list of 3 references. Please provide your materials in one document and filename as YYMMDD_LASTNAME_FIRSTNAME.
Postdoctoral Positions
Several postdoctoral fellowship positions are available within a range of expertises and interest.
Competitive prospective applicants can send an email to vandenberghe.lab@gmail.com with a CV, cover letter, and list of 3 references. Please provide your materials in one document and filename as YYMMDD_LASTNAME_FIRSTNAME.
Scientific Staff Positions
A few senior scientific staff positions are available within the Vandenberghe laboratory.
Prospective applicants can send an email to vandenberghe.lab@gmail.com with a CV, cover letter, and list of 3 references. Please provide your materials in one document and filename as YYMMDD_LASTNAME_FIRSTNAME.
Program Coordinator
POSITION SUMMARY:
A position is available to support the activities of an academic research center administratively and organizationally at the Schepens Eye Research Institute (SERI) and Massachusetts Eye and Ear Infirmary (MEEI), a Harvard Medical School teaching-affiliate. The Grousbeck Gene Therapy Center seeks to develop gene therapies for diseases of unmet need, build enabling gene transfer technologies, and deepen our understanding of the biology of gene transfer.
The Program Coordinator will provide support to the Director of the Center and be the administrative liaison for the research laboratory and core facilities. This is a position with a high-level responsibility and requires flexibility, high energy, and eagerness to work in an energetic, fast paced, friendly, and academic environment.
The incumbent will work alongside Research Faculty to support all activities within their research program, including but not limited to collaborating with grant administrators for appropriate use of grant and research funds, Human Resources (HR) to successfully onboard new personnel, Development for potential funding opportunities, and providing administrative support via calendar management, purchase and expense reconciliation, travel planning, and updating curriculum vitae and biosketches.
ESSENTIAL FUNCTIONS:
EDUCATION AND EXPERIENCE:
WORKING CONDITIONS:
20 Staniford Street, Boston, MA 02114
Onsite position, flexible up to one day weekly remote work after probation period
PHYSICAL REQUIREMENTS:
Mental and visual attention requiring a combination of alertness and manual dexterity, with a minimum of 40 words per minute typing speed using a PC. Ability to lift 20 lbs. as needed to assist with supply delivery to laboratories.
HIPAA Privacy Training and Sanctions
All employees who have access to health information whose confidentiality is protected by the HIPAA Privacy Rule are required by the Rule to receive training so that they have an understanding and knowledge of the Privacy Rule that corresponds to their job responsibilities and of the group health plan’s policies and procedures that impact on their job duties. Training on the requirements of the HIPAA Privacy Rule and the plan’s health information policies and procedures under the direction of the institution’s privacy officer is a pre-requisite for this position.
Employees who violate the requirements of the HIPAA Privacy Rule will be subject to discipline, up to and including termination.