Mohammadsharif Tabebordbar, Ph.D.
Title: Postdoctoral Fellow
Educational Background: BSc in Biotechnology, Department of Biotechnology, College of Sciences, University of Tehran, Tehran, Iran; MSc in Molecular Biotechnology, Department of Biotechnology, College of Sciences, University of Tehran; Ph.D. in Developmental and Regenerative Biology, Harvard Medical School, Boston, MA.
Research Projects: AAV engineering for development of potent gene therapy vehicles
Research Interests: Gene therapy and gene editing for different forms of muscular dystrophy
Career Ambition: To contribute to development of effective therapeutics for genetic muscle diseases
Awards/Honors: Royan International Research Award in Regenerative Medicine (August 2016). Excellence in Research Award, abstract selected as one of the top six submitted to the American Society of Gene and Cell Therapy (ASGCT) 19th annual meeting (Spring 2016). Meritorious Abstract Travel Award, ASGCT 19th annual meeting (Spring 2016). Nominated as one of the two representatives of Harvard Medical School to participate in the nationwide Regeneron prize competition for creative innovation (2014). Albert J. Ryan Foundation Award for Outstanding Graduate Students in Biomedical Sciences (2014). Distinction in Teaching Award from Derek Bok Center for Teaching and Learning at Harvard (2013). Distinction in Teaching Award from Derek Bok Center for Teaching and Learning at Harvard (2012).
1. Wei Leong Chew*, Mohammadsharif Tabebordbar*, Jason K.W. Cheng, Prashant Mali, Elizabeth Y. Wu, Alex H M Ng, Kexian Zhu, Amy J. Wagers, George M. Church, A multifunctional AAV–CRISPR–Cas9 and its host response, Nature Methods, 2016 Sep 5, doi:10.1038/nmeth.3993 * Equally contributed
2. Mohammadsharif Tabebordbar*, Kexian Zhu*, Jason K.W. Cheng, Wei Leong Chew, Jeffrey J. Widrick, Winston X. Yan, Claire Maesner, Elizabeth Y. Wu, Ru Xiao, F. Ann Ran, Le Cong, Feng Zhang, Luk H. Vandenberghe, George M. Church, Amy J. Wagers, In vivo gene editing in dystrophic mouse muscle and muscle stem cells, Science, 2015 Dec 31, DOI: 20.1126. Featured in the New York Times, the Guardian and the Science Magazine. * Equally contributed
3. Cong Xu*, Mohammadsharif Tabebordbar*, Salvatore Iovino*, Jingxia Liu, Alessandra Castiglioni, Emily Price, Min Liu, Elisabeth R Barton, C. Ronald Kahn, Amy J. Wagers, Leonard I. Zon, A Zebrafish Embryo Culture System Defines Factors that Promote Vertebrate Myogenesis across Species, Cell, 2013 Nov 7; 155 (4): 909-21. Cover publication* Equally contributed
4. Lior Zangi, Kathy O Lui, Alexander von Gise, Qing Ma, Wataru Ebina, Leon M Ptaszek, Daniela Später, Huansheng Xu, Mohammadsharif Tabebordbar, Rostic Gorbatov, Brena Sena, Matthias Nahrendorf, David M Briscoe, Ronald A Li, Amy J Wagers, Derrick J Rossi, William T Pu, Kenneth R Chien. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nature Biotechnology, 31, 898–907 (2013)
5. Carla A. Klattenhoff, Johanna C. Scheuermann, Lauren E. Surface, Robert K. Bradley, Paul A. Fields, Matthew L. Steinhauser, Huiming Ding, Vincent L. Butty, Lillian Torrey, Simon Haas, Ryan Abo, Mohammadsharif Tabebordbar, Richard T. Lee, Christopher B. Burge, and Laurie A. Boyer. Braveheart, a long noncoding RNA required for cardiovascular lineage commitment, Cell, 2013 Jan 31;152(3):570-83.
6. Mohammadsharif Tabebordbar, Eric T. Wang, Amy J. Wagers. Skeletal Muscle Degenerative Diseases and Strategies for Therapeutic Muscle Repair, Annual Review of Pathology: Mechanisms of Disease, 2013 Jan 24;8:441-75.
7. Ali Seifinejad, Mohammadsharif Tabebordbar, Hossein Baharvand, Laurie A. Boyer, Ghasem Hosseini Salekdeh. Progress and promise towards safe induced pluripotent stem cells for therapy, Stem cell reviews and reports. 2010 Jun; 6(2):297-306.
8. Ali Fathi, Mohammad Pakzad, Adele Taei, Thore C. Brink, Leila Pirhaji, Guifre´ Ruiz, Mohammad Sharif Tabe Bordbar, Hamid Gourabi, James Adjaye, Hossein Baharvand, and Ghasem Hosseini Salekdeh. Comparative proteome and transcriptome analyses of embryonic stem cells during embryoid body-based differentiation, Proteomics, 9, 4859–4870, 2009.
9. Mehdi Totonchi, Adeleh Taei, Ali Seifinejad, Mohammadsharif Tabebordbar, Hassan Rassouli, Ali Farrokhi, Hamid Gourabi, Nasser Aghdami, Ghasem Hosseini Salekdeh, Hossein Baharvand. Feeder- and Serum-Free Establishment and Expansion of Human Induced Pluripotent Stem Cells, International journal of developmental biology. 2010;54(5):877-86.
10. Mahboobeh Kabiri, Mohammad Ali Amoozegar, Mohammadsharif Tabebordbar, Kambiz Gilani, Ghasem Hosseini Salekdeh. Effects of selenite and tellurite on growth, physiology and proteome of a moderately halophilic bacterium. Journal of proteome research. 2009 Jun;8(6):3098-108.