Eva Andres-Mateos, PhD
Title: Project Manager and Associate Director of Quality Assurance, Assays and Process Development
Educational Background: PharmD, Universidad Complutense de Madrid (Spain); PhD Pharmacology-Neurosciences, Universidad Autonoma de Madrid (Spain); Postdoctoral Fellow, Department of Neurology-Johns Hopkins School of Medicine (US); Postdoctoral Fellow, Department of Genetic Medicine-Johns Hopkins School of Medicine (US)
Research Project: Gene therapy in the CNS and muscle
Research Interest: Neurodegenerative and neuromuscular disorders, translational gene therapy research, molecular pathways of neurodegeneration, mitochondrial biogenesis
Career Ambition: Contribute to the development of translational gene therapy programs
Membership: Society for Neurosciences
Awards and Honors: Helen B Taussig Johns Hopkins Young Investigator Award; MEC/Fulbright; Postdoctoral Research Fellowship; Postdoctoral Fellowship Fundacion Ramon Areces; International Research Travel Award, Universidad Autonoma ; Predoctoral Research Felowship, Universidad Autonoma; SOCRATES-ERASMUS Scholarship
1. E. Zinn et al., In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector. Cell reports 12, 1056 (Aug 11, 2015).
2. E. M. MacDonald et al., Denervation atrophy is independent from Akt and mTOR activation and is not rescued by myostatin inhibition. Disease models & mechanisms 7, 471 (Apr, 2014).
3. R. Xu et al., Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization. Experimental neurology 247, 392 (Sep, 2013).
4. E. Andres-Mateos et al., Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy. EMBO molecular medicine 5, 80 (Jan, 2013).
5. E. Andres-Mateos et al., Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels. PloS one 7, e48884 (2012).
6. E. L. Finanger Hedderick et al., Loss of sarcolemmal nNOS is common in acquired and inherited neuromuscular disorders. Neurology 76, 960 (Mar 15, 2011).
7. A. M. de Lucas-Cerrillo et al., Function of partially duplicated human alpha77 nicotinic receptor subunit CHRFAM7A gene: potential implications for the cholinergic anti-inflammatory response. The Journal of biological chemistry 286, 594 (Jan 7, 2011).
8. T. N. Burks et al., Losartan restores skeletal muscle remodeling and protects against disuse atrophy in sarcopenia. Science translational medicine 3, 82ra37 (May 11, 2011).
9. E. Andres-Mateos et al., Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). The Journal of neuroscience : the official journal of the Society for Neuroscience 29, 15846 (Dec 16, 2009).
10. E. Andres-Mateos et al., DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proceedings of the National Academy of Sciences of the United States of America 104, 14807 (Sep 11, 2007).
11. R. Serantes et al., Interleukin-1beta enhances GABAA receptor cell-surface expression by a phosphatidylinositol 3-kinase/Akt pathway: relevance to sepsis-associated encephalopathy. The Journal of biological chemistry 281, 14632 (May 26, 2006).
12. E. Andres-Mateos et al., Bovine CACNA1A gene and comparative analysis of the CAG repeats associated to human spinocerebellar ataxia type-6. Gene 380, 54 (Sep 15, 2006).
13. E. Andres-Mateos et al., Dynamic association of the Ca2+ channel alpha1A subunit and SNAP-25 in round or neurite-emitting chromaffin cells. The European journal of neuroscience 22, 2187 (Nov, 2005).
14. L. M. Solis-Garrido et al., Cross-talk between native plasmalemmal Na+/Ca2+ exchanger and inositol 1,4,5-trisphosphate-sensitive ca2+ internal store in Xenopus oocytes. The Journal of biological chemistry 279, 52414 (Dec 10, 2004).
15. P. Baldelli et al., Direct and remote modulation of L-channels in chromaffin cells: distinct actions on alpha1C and alpha1D subunits? Molecular neurobiology 29, 73 (Feb, 2004).
16. M. Aldea et al., A perforated patch-clamp study of calcium currents and exocytosis in chromaffin cells of wild-type and alpha(1A) knockout mice. Journal of neurochemistry 81, 911 (Jun, 2002).
17. E. Garcia-Palomero et al., Differential expression of calcium channel subtypes in the bovine adrenal medulla. Neuroendocrinology 74, 251 (Oct, 2001).
18. F. Arnalich et al., Intracellular glutathione deficiency is associated with enhanced nuclear factor-kappaB activation in older non-insulin dependent diabetic patients. Free radical research 35, 873 (Dec, 2001).